Depends on the kind of game. Angles: 30 / 45 / 60 degree Beside this you need a lot of tiles and an isometric engine, that is able to deep sort the tiles correctly, so you have the "front - back feeling" which is needed to fake the 3d environment.
I tried the isometric method for a while until I realised that stacking tiles in a vertical/horizontal configuration will look and behave just the same. If you're interested, download the rpg engine in my sig and see what I mean.
For sorting the tiles, I gave them all z values and made the engine sort them for me. It works well.